How to use the dosing calculator
The table below shows the dose of Sialanar® (for patients with normal renal function) to prescribe in millilitres based on the weight of the child and the titration level they are at in the dosing regimen. Sialanar® contains 320 micrograms of the active ingredient, glycopyrronium per ml of liquid which is EQUIVALENT TO 400 micrograms of the salt glycopyrronium bromide, per ml.
Summary of Product Characteristics (UK)
Ireland Prescribing Information
Summary of Product Characteristics (Ireland)
Hover over the weight of the child and move the cursor along until the desired dose level is reached (light blue lines will appear). The appropriate dose of Sialanar® in mls will be shown in dark blue. This dose should be given three times a day, increasing to the doses shown every 7 days, to balance efficacy and tolerability.
NB – When viewing the chart on a smartphone or tablet please view it in landscape mode.
| Active or Salt | Dose Level 1 | Dose Level 2 | Dose Level 3 | Dose Level 4 | Dose Level 5 |
| 320 µg/ml glycopyrronium | (~12.8µg/kg) | (~25.6µg/kg) | (~38.4µg/kg) | (~51.2µg/kg) | (~64µg/kg) |
| 400 µg/ml (2mg/5ml) glycopyrronium bromide |
(~16.0µg/kg) | (~32.0µg/kg) | (~48.0µg/kg) | (~64.0µg/kg) | (~80.0µg/kg) |
| Weight Kg | ml | ml | ml | ml | ml |
| 13-17 | 0.6 | 1.2 | 1.8 | 2.4 | 3* |
| 18-22 | 0.8 | 1.6 | 2.4 | 3.2 | 4* |
| 23-27 | 1 | 2 | 3 | 4 | 5* |
| 28-32 | 1.2 | 2.4 | 3.6 | 4.8 | 6* |
| 33-37 | 1.4 | 2.8 | 4.2 | 5.6 | 6* |
| 38-42 | 1.6 | 3.2 | 4.8 | 6* | 6 |
| 43-47 | 1.8 | 3.6 | 5.4 | 6* | 6 |
| ≥48 | 2 | 4 | 6* | 6 | 6 |
* Maximum dose for this weight/dose level
Please see Sialanar®’s SmPC (Section 4.2, Table 2) for dosing details in children and adolescents with mild to moderate renal impairment.
The table below shows the dose of glycopyrronium bromide in milligrams for each 0.2mls of Sialanar®.
| mls of Sialanar® | mg of glycopyrronium bromide |
mls of Sialanar® | mg of glycopyrronium bromide |
|
| 0.2 | 0.08 | 3.2 | 1.28 | |
| 0.4 | 0.16 | 3.4 | 1.36 | |
| 0.6 | 0.24 | 3.6 | 1.44 | |
| 0.8 | 0.32 | 3.8 | 1.52 | |
| 1.0 | 0.40 | 4.0 | 1.60 | |
| 1.2 | 0.48 | 4.2 | 1.68 | |
| 1.4 | 0.56 | 4.4 | 1.76 | |
| 1.6 | 0.64 | 4.6 | 1.84 | |
| 1.8 | 0.72 | 4.8 | 1.92 | |
| 2.0 | 0.80 | 5.0 | 2.00 | |
| 2.2 | 0.88 | 5.2 | 2.08 | |
| 2.4 | 0.96 | 5.4 | 2.16 | |
| 2.6 | 1.04 | 5.6 | 2.24 | |
| 2.8 | 1.12 | 5.8 | 2.32 | |
| 3.0 | 1.20 | 6.0 | 2.40 |
Paediatric population – children and adolescents aged 3 years and older
The dosing schedule for glycopyrronium is based on the weight of the child, starting with approximately 12.8 micrograms/kg per dose (equivalent to 16 micrograms/kg per dose glycopyrronium bromide), three times per day and increasing by the doses shown in the table above, every 7 days. Dose titration should be continued until efficacy is balanced with undesirable effects and amended up or down, as appropriate, to a maximum individual dose of 64 micrograms/kg body weight glycopyrronium or 6 ml (1.9 mg glycopyrronium, equivalent to 2.4 mg glycopyrronium bromide) three times a day, whichever is less.
Dose titration should be continued until efficacy is balanced with undesirable effects and amended up or down as appropriate, to a maximum individual dose of 64 micrograms/kg body weight glycopyrronium or 6 ml (1.9 mg glycopyrronium, equivalent to 2.4 mg glycopyrronium bromide) three times a day, whichever is less. Dose titrations should be conducted in discussion with the carer to assess both efficacy and undesirable effects until an acceptable maintenance dose is achieved.
Please refer to the full Summary of Product Characteristics (SmPC) before prescribing.
Please see information below to report adverse events in the UK
Please see information below to report adverse events in the Republic of Ireland
UK-SIA-23-0098
Updated June 2023